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GLP1RAs can be categorized as short-acting or long-acting according to their timeaction profile
The starting dose is conservative and designed for tolerability, so many patients see their pace of weight loss pick up after the first dose increase
Even after stopping semaglutide, improvements in hormonal profiles - such as lower free testosterone levels - are maintained when metformin is continued
The weight loss machinery is warming up, not stalling
First, some of the muscle change happens with any rapid weight loss, and a portion may be a normal adjustment to a smaller body rather than harmful wasting (Mocciaro and colleagues, BMJ Nutrition Prevention and Health , 2025)
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